Inventi Rapid: Animal Models & Cell Assays

Inventi:prac/30796/21

An Evaluation of CNS Depressant Activity of Levetiracetam on Experimental Mice Using Different Animal Models

The aim of the present study was designed to evaluate the CNS depressant activity of “levetiracetam” using different animal models. The degree of CNS depressant activity was determined by measuring the immobility time in muscle coordination test, locomotor activity and forced swim test. In this study animals treated with the doses of levetiracetam (50 and 100 mg/kg). The degree of CNS depressant activity was determined by measuring the immobility time in muscle coordination test, locomotor activity and forced swim tests. Animals treated with all three doses of levetiracetam (50 and 100 mg/kg) witnessed a decreased muscle coordination test, locomotor activity and forced swim test. This was significant when compared with control. Similarly, animals treated with diazepam (4 mg/kg), as expected to show a significant decrease in muscle coordination test, locomotor activity and forced swim test. The experimental results conclude that levetiracetam has CNS depressant activity. But in contrast to standard drug i.e. diazepam it was found to be less. Therefore the levetiracetam may be considered as CNS depressant for further study....